Table 5: Description of Failed Challenge Reactions.

Symptom categories were derived from PRACTALL guidelines and definitions of reactions.

	Overall (n=30)	Grade 2/3 Reaction (n=21)	Anaphylactic Reaction (n=3)
Percent Ingested, mean (sd)	37.0 (38.3)	39.8 (41.8)	57.0 (60.8)
Reaction Symptoms: Subjective
Oral Itching	8 (27%)	3 (14%)	0 (0%)
Pruritus	8 (27%)	6 (29%)	1 (33%)
Nausea	2 (7%)	2 (10%)	0 (0%)
Abdominal Pain	3 (10%)	3 (14%)	1 (33%)
Irritability	2 (7%)	2 (10%)	0 (0%)
Dizziness	0 (0%)	0 (0%)	0 (0%)
Reaction Symptoms: Objective
Hives / Angioedema	17 (57%)	17 (81%) ***	2 (67%)
Non-urticarial Rash	3 (10%)	1 (5%)	0 (0%)
Flushing (local)	6 (20%)	3 (14%)	1 (33%)
Flushing (generalized)	0 (0%)	0 (0%)	0 (0%)
Nasal symptoms	12 (40%)	10 (48%)	3 (100%)
Wheeze	2 (7%)	2 (10%)	2 (67%)*
Laryngeal symptoms†	1 (3%)	1 (5%)	0 (0%)
Vomiting	3 (10%)	3 (14%)	1 (33%)
Diarrhea	0 (0%)	0 (0%)	0 (0%)
Tachycardia	1 (3%)	1 (5%)	1 (33%)
Low blood pressure	0 (0%)	0 (0%)	0 (0%)
Reaction Treatment
Treatment given	21 (70%)	14 (67%)	3 (100%)
Antihistamines	21 (70%)	14 (67%)	3 (100%)
H2 blocker	3 (10%)	3 (14%)	2 (67%)*
Steroid	2 (7%)	2 (10%)	2 (67%)*
Albuterol	1 (3%)	1 (5%)	1 (33%)
Epinephrine	2 (7%)	2 (10%)	2 (67%)*

^†In this cohort, the 1 subject experiencing laryngeal symptoms had throat clearing.

^*p<0.05

^**p<0.01

^***p<0.001