FIG 3.

HIV infection is associated with decreased M. tuberculosis-specific isotype and subclass titers during ATB. Relative levels of the indicated antibody isotype/subclass specific to PPD (A), LAM (B), Ag85A/B (C), and ESAT6/CFP10 (D) present in the plasma of the study population were determined via Luminex. Following data collection, a Z-score transformation was applied to each antibody variable. Next, the median value of each infection group was graphed to summarize group reactivity to each antigen. Kruskal-Wallis with Dunn’s multiple-comparison test was performed on the untransformed data to assess significance. Adjusted P values are as follows: *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. Statistical significance comparing ATB/HIV+ and LTBI/HIV−, as well as ATB/HIV− and LTBI/HIV+, are not shown here (see Fig. S1 and S2).