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. 2020 Jul 24;15(7):e0236363. doi: 10.1371/journal.pone.0236363

Fig 3. The effect of (+)-bicuculline on the 40 Hz ITC.

Fig 3

a, Heat map representation of mean time-frequency plots of ASSR at 40-Hz stimulation at −10 (baseline), 10, 30, 70 and 110 min following (+)-bicuculline (0, 1, 2 and 4 mg/kg, sc) treatment, as shown for ERSP in Fig 2. b, Time-course of the 40 Hz ITC following (+)-bicuculline treatment. The 40 Hz ITC was significantly reduced in bicuculline (2 and 4 mg/kg)-treated rats than vehicle-treated rats. c, Effect of bicuculline on the 40 Hz ITC at 30 min, the time at which bicuculline achieves Cmax. No statistically significant effect was observed on ITC with bicuculline treatment. Values are mean ± SEM. The number of rats was 12 in each group.