Fig 3. Paclitaxel-DCH depots persist locally for up to 4 weeks in vivo and are superior at preserving viable adjacent healthy CNS tissue compared to paclitaxel in Cremophor EL vehicle.

A. CD68 positive cells are present at the DCH-paclitaxel interface for up to 4 weeks post injection but there is minimal diminution of the depot size, minimal material resorption and minimal infiltration of inflammatory cells into the DCH-paclitaxel depot. B. NeuN positive, viable neurons are present in normal density and intermingled with mildly reactive astrocytes in close proximity with the DCH-paclitaxel depot (DCH-Pac). C. In contrast, there is pronounced depletion of NeuN positive neurons and severe proliferative reactive astrogliosis in tissue adjacent to injection of paclitaxel in Cremophor EL vehicle (Crem-Pac). Scale bar, 200 μm for all images. N = 3 mice per stain per treatment.