Table 2. Evolution of the receiver operating characteristics statistics for selected biomarkers over the course of disease.

Classification between the dengue and OFI groups. First contact: day of first contact with healthcare (independently of the day of fever). Median days -2 to 1: a posteriori calculation of the biomarker’s median value between D-2 and D+1. AUC: area under the curve; CI: confidence interval.

		Day
Variables		First Contact	-2	-1	0	1	Median days -2 to 1
White blood cells, *1000/μl	Best cutoff, Youden index	5.25	5.55	3.95	3.35	4.25	4.08
	AUC	0.76	0.82	0.89	0.79	0.67	0.8
	95% CI AUC	0.66–0.86	0.70–0.94	0.82–0.96	0.7–0.87	0.56–0.77	0.72–0.89
Neutrophils, %	Best cutoff, Youden index	84.5	57.5	72	51.5	47.5	51.75
	AUC	0.5	0.6	0.58	0.63	0.7	0.66
	95% CI AUC	0.38–0.61	0.37–0.83	0.44–0.72	0.52–0.74	0.6–0.8	0.56–0.76
Lymphocytes, %	Best cutoff, Youden index	11.5	36.5	25.5	33.5	51.5	38.25
	AUC	0.51	0.61	0.57	0.65	0.72	0.67
	95% CI AUC	0.40–0.63	0.39–0.82	0.43–0.71	0.54–0.76	0.62–0.82	0.57–0.77
Platelets, *1000/μl	Best cutoff, Youden index	194.5	199.5	170	157.5	166.5	160
	AUC	0.74	0.76	0.81	0.85	0.88	0.84
	95% CI AUC	0.64–0.83	0.61–0.90	0.7–0.92	0.78–0.92	0.81–0.95	0.76–0.92
Thrombin Time, difference in sec	Best cutoff, Youden index	3.3	0.1	2.45	2.8	1.95	1.75
	AUC	0.7	0.69	0.73	0.85	0.71	0.8
	95% CI AUC	0.59–0.80	0.49–0.88	0.62–0.85	0.77–0.92	0.6–0.82	0.72–0.88