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. Author manuscript; available in PMC: 2020 Jul 24.
Published in final edited form as: Nature. 2019 Oct 23;574(7780):686–690. doi: 10.1038/s41586-019-1688-z

Fig. 2: The NO precursor L-arginine prevents the increase in p-tau induced by HSD.

Fig. 2:

a–c, Administration of L-arginine (10 g/L in drinking water), starting at week 8 of HSD and continued through week 12, suppresses AT8 accumulation in neocortex and hippocampus (CTX: Veh, ND/HSD n=10/10; L-Arg – ND/HSD n=16/21, *p=0.0045 vs ND; HIPP: Veh, ND/HSD n=10/8; L-Arg – ND/HSD n=7/12, *p=0.0067 vs ND, two-tailed unpaired t-test). d,e, L-arginine treatment improves the cognitive deficits induced by HSD in both the novel object recognition test (Veh – ND/HSD n=12/10, L-Arg – ND/HSD n=6/11; Diet: *p=0.0156, Treatment: *p=0.0406, two-way ANOVA and Tukey’s test) and the Barnes Maze (Primary Latency, Diet: *p=0.0182, Time: *p<0.0001, two-way RM ANOVA plus Tukey’s test; Primary Latency, Day 5, *p=0.0439, Kruskal-Wallis test). For gel source data see supplementary figure 1. Data are expressed as mean±SEM.