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. Author manuscript; available in PMC: 2020 Jul 24.
Published in final edited form as: Science. 2019 Mar 29;363(6434):1418–1423. doi: 10.1126/science.aav7541

Fig. 1. Noncovalent forces in MP folding.

Fig. 1.

(A) Polar interactions are known to stabilize MP structures. (B) vdW packing is abundant in the folded state, but similar interactions with membrane lipids occur in the unfolded state; it is unknown whether packing alone can drive MP folding. (C) Overview of the multipronged approach used.