Table 3.
Factors associated with OS in patients with NSCLC
| Characteristics | HR | 95% CI | P value |
| Age | |||
| >75 years | 0.99 | 0.40–2.43 | 1 |
| <75 years | 1 (reference) | ||
| Gender | |||
| Female | 1.42 | 0.66–3.05 | 0.4 |
| Male | 1 (reference) | ||
| Brain metastases | |||
| Presence | 1.48 | 0.70–3.11 | 0.3 |
| Absence | 1 (reference) | ||
| Histological type | |||
| Non-squamous cell carcinoma | 0.83 | 0.34–2.05 | 0.7 |
| Squamous cell carcinoma | 1 (reference) | ||
| PDL1 expression | |||
| ≥50% | 0.80 | 0.44–3.55 | 0.7 |
| <50% | 1 (reference) | ||
| Previous chemotherapy | |||
| None | 2.09 | 0.84–5.19 | 0.11 |
| ≥1 | 1 (reference) | ||
| MTV | |||
| >36.5 | 5.37 | 2.17–13.3 | <0.0001 |
| <36.5 | 1 (reference) | ||
| TLG | |||
| >267 | 5.05 | 2.05–12.5 | 0.0001 |
| <267 | 1 (reference) | ||
| SUVmax | |||
| >13.4 | 1.31 | 0.63–2.75 | 0.5 |
| <13.4 | 1 (reference) | ||
| SUVpeak | |||
| >9.7 | 1.15 | 0.55–2.40 | 0.7 |
| <9.7 | 1 (reference) |
Log-rank test results. MTV, TLG.
Median values were used for cut-off.
MTV, metabolic tumor volume; NSCLC, non-small cell lung cancer; OS, overall survival; PDL1, programmed death receptor ligand 1; SUVmax, maximum standardized uptake value; SUVpeak, peak standardized uptake value; TLG, total lesion glycolysis.