(
A) Voltage-current dependence, (
B) resting membrane potential, (
C) input resistance, (
D) membrane capacitance and (
F) rheobase were unchanged in 6-OHDA and chronic-LD groups. (
E) Ramp protocol for rheobase determination. Recordings in A-D were recorded in whole-cell mode in the presence of 1 µM TTX (n = 12–34 neurons/4–9 mice per group). (
G) Representative and (
H) averaged traces and shape characteristics (
I) of sAPs from the three experimental groups (n = 21–27 neurons/8–10 mice per group). (
J) Current protocol (lower) and representative trace (upper) of action potentials evoked by 100 pA current injection. (
K, L) Shape characteristics of action potentials evoked by 100 pA current injection (n = 19–28 neurons/8–11 mice per group). p<0.05 (*) or p<0.01 (**) by Kruskal-Wallis test with Dunn’s multiple comparison analysis. Exact
n for each figure are listed in
Figure 1—source data 1.