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. 2020 Jul 22;8(1):e001126. doi: 10.1136/bmjdrc-2019-001126

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Results from the integrative network analysis of hepatic fat and abdominal fat deposition, clinical biomarkers, and plasma metabolomics data in 283 children and adolescents in the Yale Pediatric NAFLD Cohort. Communities detected by the multilevel community detection algorithm are indicated by different colors. Associations were selected by partial least squares regression based on thresholds of r|>0.15 and p<0.05. ALT, alanine aminotransferase; BP, blood pressure; ESI, electrospray ionization; HDL, high-density lipoprotein; HILIC, hydrophilic liquid interaction chromatography; HOMA-IR, homeostatic model assessment of insulin resistance; m/z, mass to charge ratio; NAFLD, non-alcoholic fatty liver disease; SAT, subcutaneous adipose tissue; WBISI, whole body insulin sensitivity index.