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. 2020 Jul 22;40(30):5757–5768. doi: 10.1523/JNEUROSCI.2369-19.2020

Figure 4.

Figure 4.

Basal synaptic transmission is not affected in IP3R2−/− mice. A, Experimental configuration in horizontal brain slices of IP3R2−/− and wild-type (WT) littermates. B, Changes in EPSC amplitude evoked by different stimulus intensities in IP3R2−/− (light red, n = 5, 2 mice) and WT littermates (red, n = 5, 2 mice; F(1,5) = 86.10, RM1WA, p = 0.07). C, left, Representative traces of miniature EPSCs (mEPSCs) in IP3R2−/− (bottom) and WT littermates (top). Right, Mean mEPSC amplitude (pA) in IP3R2−/− (red, n = 6, 2 mice) and WT littermates (light red, n = 6, 2 mice, t = 0.00,019, df = 10, p = 0.99, t test) and mean mEPSC/min in IP3R2−/− (red, n = 6, 2 mice) and WT littermates (light red, n = 6, 2 mice, t = 0.07, df = 10, p = 0.94, t test).