Table 3.

Difficulties associated with activities of the in-person visit and their correction measures.

Study activity and associated difficulties or risks		Measures to correct or mitigate
Presentation protocol and signing informed consent
	Participants decide not to participate	Summarize by phone so that they can assess whether to participate (avoid visit if uninterested)
	Participants do not understand the function	Explain in a simple and clear way the protocol and benefits (eg, “measure your sleep...”)
Patient questionnaires
	Patients do not meet the inclusion criteria	Clearly specify the criteria and instruments when explaining the protocol and review medical history
Download of the app
	Lack of storage space on phone	Forewarn the participant before the visit that an app will need to be downloaded
Instructions of use
	Misuse of the app or device	Deliver a clear, visual instruction notebook in the first session Rehearse app use during the visit with patient Provide contact information to call in case of difficulties
Explaining the follow-up
	Participants forget to respond to questionnaires	Prepare a specific calendar for the patients, showing schedule of days to respond to the questionnaires, and schedule a date for the second in-person visit
	Participants forget to wear the device daily	Send weekly reminders