Table 4.

Illustrative quotes related to using the self-management app: enzyme dose calculation.

Id	Concern	Interviewee	Quote
E1	Increased knowledge	Mother of a 5-year-old child, C4	“Before we just looked at the calories. Every 100 calories, we gave 1 “10 000” pills. But we learnt that, for the Creon, it is not as straightforward. For mayonnaise, we gave too little and now we know. After using the app, he gained much more weight.”
E2	Feeling confident	Mother of a 5-year-old child, C5	“At the beginning, I was really afraid because the doses were very high and I was scared to give this to my son, but then we decided to try. We were checking what we had entered to the app in the case it was very fatty. I felt comfortable because everything in the app is well measured. [...] Yes, I felt comfortable and there were no side effects.”
E3	Developing best practices	Mother of a 7-year-old teen, C1	“Sometimes I gave her X pills for a specific meal. But later on, she doesn’t want to finish up the dish. So, I wonder, what can I do? I learnt that I can give her some walnuts. It is a highly caloric food that she likes. Eating three walnuts is very easy for her, and it increases a lot the amount of Creon. I have learnt this thanks to the app. Or with the olives, it is the same.”
E4	Perceived benefits: gaining weight, better digestion	Dietician, C3	“Some increased weight. There was one patient that told us that finally he knows what normal faeces are. He said he had thought his faeces were normal, and finally they weren't.”
E5	Perceived benefit: child accountability	Mother of a 10-year-old teen, C4	“She is a teenager. Sometimes, she forgot to take her enzyme, but now she always takes it. We do not have to tell her...”
E6	Disadvantage: extra workload, but fewer symptoms	Parents of a 6-year-old child, C2	Father: “Yes, the app comes with extra workload. You have to do extra steps to calculate. But in the end, it makes it worthwhile to do it.” Mother: “Yes, we see when she goes to the toilets, it is much better. That’s worthy.”
E7	Behaviors in response to the recommended dose	Doctor, C2	“It was different. There were people who did not follow the advice and did just use their own usual dosage. And there were parents who did use the advice of the app. But, in general, if there was a big difference, they used to take their own dose.”
E8	Need for HCPa support: wrong food recording	Dietician, C2	“Because sometimes they told “We got such a weird advice. I did everything right in the app, but we have to take 8 Creon for one piece of fish.” And then it turned out that they did something wrong, and if I filled it out again, it was only like 2 Creon.”

^aHCP: health care professional.