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. 2020 Jul 20;15:1201–1212. doi: 10.2147/CIA.S254885

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© 2020 Liu et al.

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Cxcl9 activates CXCR3/ERK signaling in osteoclasts. (A) Representative photomicrographs of immunostaining of CXCR3 in cultured BMMs. Scale bar, 20 μm. (B) Representative photomicrographs of immunostaining of CXCR3 in CTSK⁺ osteoclasts in mice bone. (C) Serum-starved BMM cells were incubated with 100 ng/mL Cxcl9 for the indicated time points. Total cell lysates were immunoblotted with antibodies specifically recognizing the phosphorylated form of Src and ERK. (D) Serum-starved BMM cells were incubated with Cxcl9 (100 ng/mL) or Cxcl9 plus NBI-74,330 (CXCR3 antagonist) as indicated for 10 min. Total cell lysates were immunoblotted with antibodies specifically recognizing the phosphorylated form of Src and ERK.