Table 2.

56 identified potential biomarkers among the WKY, SHR and test compounds.

No	Fragment	tR(min)	m/z	Change				Biomarkers
				aSHR	bUET	bRT	bIT
1	[M−H]−	9.46	315.25430	↓	↑		↑	MG(15:0)
2	[M+H]+	12.57	595.52951	↑				DG(34:1)
3	[M+H]+	11.23	593.51672	↑	↓			DG(34:2)
4	[M+H]+	11.23	611.54452	↑	↓		↓	DG(35:0)
5	[M+H]+	9.22	607.51278	↑	↓			DG(35:2)
6	[M+H]+	11.30	621.53383	↑				DG(36:2)
7	[M+H]+	11.31	619.53112	↑				DG(36:3)
8	[M+H]+	10.20	617.51453	↑			↓	DG(36:4)
9	[M+H]+	10.20	635.54441	↑	↓		↓	DG(37:2)
10	[M+H]+	21.09	819.72638	↑				TG(49:1)
11	[M+H]+	21.14	845.74194	↑				TG(51:2)
12	[M+H]+	21.28	859.75805	↑			↓	TG (52:2)
13	[M+H]+	21.42	855.74175	↑				TG (52:4)
14	[M+H]+	20.94	873.69390	↑				TG (54:9)
15	[M+H]+	20.83	893.74210	↑	↓		↓	TG (55:6)
16	[M+H]+	21.65	919.85124	↑				TG (56:0)
17	[M+H]+	20.51	897.69435	↑	↓		↓	TG (56:11)
18	[M+H]+	21.41	911.78964	↑	↓		↓	TG (56:4)
19	[M+H]+	21.25	941.83068	↑	↓		↓	TG (58:0)
20	[M+H]+	20.07	921.69465	↑	↓		↓	TG (58:13)
21	[M−H]−	3.41	423.27580	↓		↑		LysoPA (18:0)
22	[M−H]−	6.16	465.30469	↓	↑	↑	↑	LysoPA (20:0)
23	[M+H]+	5.89	522.35524	↓				LysoPC (18:1)
24	[M+H]+	5.37	520.33999	↓				LysoPC (18:2)
25	[M+H]+	6.65	552.40265	↓				LysoPC (20:0)
26	[M+H]+	5.33	546.34363	↓				LysoPC (20:3)
27	[M+H]+	5.32	544.33956	↓				LysoPC (20:4)
28	[M+H]+	6.65	578.41803	↓				LysoPC (22:1)
29	[M+H]+	7.16	606.45261	↓	↑			LysoPC (24:1)
30	[M-H]-	5.01	480.30993	↓				LysoPE (18:0)
31	[M+H]+	4.81	476.27854	↓			↑	LysoPE (18:3)
32	[M+H]+	6.05	510.35628	↓				LysoPE (20:0)
33	[M+H]+	4.59	498.26282	↓			↑	LysoPE (20:5)
34	[M-H]-	16.07	661.50530	↑	↓	↓	↓	PA (34:0)
35	[M+H]+	12.95	832.66404	↓	↑			PE (32:0)
36	[M+H]+	8.59	702.50617	↓				PE (33:2)
37	[M+H]+	10.24	802.62359	↓				PE (40:1)
38	[M+H]+	10.24	800.61666	↓				PE (40:2)
39	[M+H]+	15.32	856.68942	↓	↑		↑	PE (44:1)
40	[M+H]+	6.61	815.48703	↑				PG (40:9)
41	[M+H]+	7.22	799.56799	↑				PG (38:4)
42	[M+H]+	6.65	821.52288	↑				PG (40:7)
43	[M+H]+	6.60	863.55928	↑				PI (36:2)
44	[M+H]+	6.59	840.57451	↑			↓	PS (40:4)
45	[M+H]+	10.27	677.56590	↑	↓		↓	SM (d18:0/14:0)
46	[M−H]−	12.68	298.28348	↓				Sphingosine
47	[M−H]−	4.34	277.21738	↓	↑	↑	↑	α-linolenic acid
48	[M−H]−	12.21	335.29599	↓				Docosadienoate (22:2)
49	[M−H]−	2.12	299.25947	↑				Hydroxystearic acid
50	[M−H]−	16.10	279.23315	↑	↓	↓		Linoleic acid
51	[M−H]−	0.51	181.03348	↑				Methyluric acid
52	[M−H]−	12.67	297.28013	↓				Pristanic acid
53	[M−H]−	6.67	355.26473	↓				Tetracosahexaenoic acid
54	[M−H]−	9.87	296.26777	↓				Palmitoleoyl Ethanolamide
55	[M−H]−	11.7	593.54197	↓	↑			CE(14:1)
56	[M−H]−	0.52	259.02717	↑		↓		Glucose 1-phosphate

(↑): upregulated (p < 0.05, n = 8), (↑): downregulated (p < 0.05, n = 8).

^aTrends of the SHR group compared with the WKY group of metabolites. ^bTrends of the vtest compounds compared with the SHR group of metabolites.