Table 3.
Ingenuity pathway analysis with MetPA from differential fatty acid and lipid species.
| Pathway name | Total metabolites | Hits | p | -log(p) | Holm p | FDR | Impact | KEGG |
|---|---|---|---|---|---|---|---|---|
| Glycerophospholipid metabolism | 36 | 7 | 0.000 | 16.578 | 0.000 | 0.000 | 0.477 | 00564 |
| Linoleic acid metabolism | 5 | 2 | 0.001 | 6.633 | 0.109 | 0.046 | 1.000 | 00591 |
| Sphingolipid metabolism | 21 | 3 | 0.002 | 6.402 | 0.136 | 0.227 | 0.314 | 00600 |
| alpha-Linolenic acid metabolism | 13 | 2 | 0.010 | 4.635 | 0.786 | 0.38305 | 0.333 | 00592 |
| Biosynthesis of unsaturated fatty acids | 36 | 2 | 0.067 | 2.708 | 1.000 | 1.000 | 0.000 | 01040 |
| Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 14 | 1 | 0.155 | 1.863 | 1.000 | 1.000 | 0.004 | 00563 |
| Glycerolipid metabolism | 16 | 1 | 0.175 | 1.740 | 1.000 | 1.000 | 0.012 | 00561 |
| Pentose and glucuronate interconversions | 18 | 1 | 0.195 | 1.633 | 1.000 | 1.000 | 0.000 | 00040 |
| Starch and sucrose metabolism | 18 | 1 | 0.195 | 1.633 | 1.000 | 1.000 | 0.135 | 00500 |
| Propanoate metabolism | 23 | 1 | 0.243 | 1.416 | 1.000 | 1.000 | 0.000 | 00640 |
| Glycolysis Gluconeogenesis | 26 | 1 | 0.270 | 1.310 | 1.000 | 1.000 | 0.000 | 00010 |
| Galactose metabolism | 27 | 1 | 0.279 | 1.277 | 1.000 | 1.000 | 0.010 | 00052 |
| Phosphatidylinositol signaling system | 28 | 1 | 0.288 | 1.246 | 1.000 | 1.000 | 0.002 | 04070 |
| Arachidonic acid metabolism | 36 | 1 | 0.354 | 1.038 | 1.000 | 1.000 | 0.000 | 00590 |
| Amino sugar and nucleotide sugar metabolism | 37 | 1 | 0.362 | 1.016 | 1.000 | 1.000 | 0.071 | 00520 |
| Purine metabolism | 66 | 1 | 0.555 | 0.589 | 1.000 | 1.000 | 0.061 | 00230 |
(“Total” is the total number of differential lipid species in the pathway; “hits” is the actually matched number from the user differential fatty acid and lipid species; the raw p is the original p calculated from the enrichment analysis; the “Holm p” is the p value adjusted by Holm−Bonferroni method; “impact” is the pathway impact value calculated from pathway topology analysis).