Table 2.
The effect of lncRNAs on glucose metabolism in cancers.
| Name | Year | Cancer | lncRNA | Effect on glucose metabolism | References |
|---|---|---|---|---|---|
| Zheng et al. | 2019 | Hepatocellular carcinoma | LINC01554 | Inhibit Warburg effect via degradation of PKM2 and inhibiting the Akt/mTOR signaling pathway | (109) |
| Malakar et al. | 2019 | Hepatocellular carcinoma | lncRNA MALAT1 | Promote glycolysis and inhibit gluconeogenesis by Enhancing mTOR-Mediated Translation of TCF7L2 | (110) |
| Tang et al. | 2019 | Colorectal cancer | lncRNA GLCC1 | Increase glycolytic metabolism by stabilizing c-Myc from ubiquitination | (111) |
| Feng et al. | 2019 | Colorectal cancer | LINC00504 | Increase lactate production, glucose uptake, and pentose phosphate pathway | (112) |
| Li et al. | 2019 | Esophageal cancer | LINC00184 | Promote glycolysis by enhancing the promoter methylation of PTEN | (113) |
| Ma et al. | 2019 | Pancreatic adenocarcinoma | lncRNA HOTAIR | Increase lactate production, glucose uptake and ATP production by upregulating HK-2 | (114) |
| Chen et al. | 2019 | Osteosarcoma | lncRNA HAND2-AS1 | Inhibit glucose uptake | (115) |
| Chu et al. | 2019 | Oral squamous cell carcinoma | LncRNA ELF3-AS1 | Increase glucose metabolism by upregulating GLUT1 | (116) |
| Cheng et al. | 2019 | Glioblastoma | lncRNA-XIST | Promote glucose metabolism by acting as a miR-126 sponge | (117) |
| Li et al. | 2018 | Hepatocellular carcinoma | lncRNA Ftx | Increase Warburg effect by influencing the PPAR signaling pathway | (118) |
| Kang et al. | 2018 | Osteosarcoma | lncRNA HAND2-AS1 | Inhibit glucose uptake and lactate production | (119) |
| Han et al. | 2018 | Osteosarcoma | lncRNA TUG1 | Increase glucose consumption and lactate production by upregulating HK-2 | (120) |
| Sun et al. | 2018 | Acute myeloid leukemia | lncRNA ANRIL | Increase glucose uptake by inhibiting AdipoR1-AMPK/SIRT1 signaling pathway | (121) |
| Zhang et al. | 2018 | Acute myeloid leukemia | lncRNA UCA1 | Promote glycolysis through the microRNA-125a/HK-2 pathway | (122) |
| Yang et al. | 2018 | Multiple myeloma | lncRNA PDIA3P | Increase G6PD expression and pentose phosphate pathway | (123) |
| Wang et al. | 2018 | Oral squamous cell carcinoma | lnc-p23154 | Promote glycolysis by facilitating GLUT1 expression and inhibiting miR-378a-3p transcription | (124) |
| Xing et al. | 2018 | Breast cancer | LINC00538 (YIYA) | Promote glycolysis by regulating CDK6-dependent phosphorylation of the fructose bisphosphatase PFK2 | (91) |
| Luan et al. | 2018 | Malignant melanoma | lncRNA H19 | Promote glucose metabolism by acting as a miR-106a-5p sponge | (125) |
| Wei et al. | 2017 | Hepatocellular carcinoma | lncRNA HOTAIR | Promote glycolysis via mTOR/GLU1 pathway | (126) |
| Song et al. | 2017 | Osteosarcoma | lncRNA Pvt1 | Increase glucose uptake and lactate production by regulating miR-497/HK2 axis | (127) |
| Hu et al. | 2017 | Bladder cancer | lncRNA CASC8 | Inhibit glycolysis by interacting with FGFR1 | (128) |
| Rupaimoole et al. | 2016 | Ovarian cancer | lncRNA NRCP | Promote glycolysis by activating STAT1 transcriptional gene network | (129) |
| Li et al. | 2014 | Bladder cancer | lncRNA UCA1 | Promote glycolysis through the mTOR-STAT3/microRNA143 pathway | (130) |