TABLE 2.

Rat LRRK2 KO models.

Rat LRRK2 KO models	Author(s), year(s)	Model	Background (strain)	DA neuronal loss	Locomotor/behavioral changes	Other notes
1	(Baptista et al., 2013; Ness et al., 2013; Daher et al., 2014; Miklavc et al., 2014; Arranz et al., 2015; Boddu et al., 2015) (MJFF Comparison Study – Rats) (Charles River-SAGE).	LRRK2 KO by 10 bp deletion in exon 30 resulting in premature stop codon [rat LRRK2 (−/−)].	Outbred Long-Evans.	No loss, age not indicated (Daher).	LRRK2 KO rats show increased forelimb and hindlimb grip strength and decreased TH+ neurons in SN (MJFF Comparison study of rats - data not published caution required).	LRRK2 KO rats are protective from α-synuclein injection (Daher). Increased body weight (Ness). LRRK2 KO primary neurons have slowed clathrin-mediated endocytosis and decreased SVs in vitro (Arranz).