TABLE 7.

Drosophila dLRRK KO models.

	Author(s), year(s)	Model	DA neuronal loss	Locomotor/behavioral changes
Drosophila dLRRK KO Models
1	Dodson et al., 2014	Partial loss by early stop codon [dLRRK (+/−)].	No change in PPM1/2, PPM3, PPL1, PPL2, VUM, and PAL clusters.	Not assessed.
2	Lee et al., 2007; Imai et al., 2008; Wang D. et al., 2008; Tain et al., 2009	KO of dLRRK by piggy-BAG insertion [dLRRK (−/−)].	Loss of TH staining is decreased in DM and PM clusters at 3 and 10 days (Lee). No loss in PPM1/2, PPL1, PPM3 (Imai). No change in number or distribution (Wang). No change in PPL1 cluster (Tain).	Climbing deficits at 3 days and loss of fertility in females (Lee). Smaller abdomen and decreased fertility (Imai). No behavioral abnormality or decrease in fertility (Wang). Tendency for decreased climbing ability (Tain).
3	Lee et al., 2007	KO of dLRRK by deletion of 3′ UTR region and EP element [dLRRK (−/−)].	Not assessed.	Climbing deficits at 3 days and loss of fertility in females (data not shown).