Table 1.
References | Study design | Subjects (n) | Age, years (mean ± SD) | Disease/symptom | Kampo formulation | Comparator | Outcome | Adverse reaction |
---|---|---|---|---|---|---|---|---|
Uchida (12) | RCT | 12 | 65.8 ± 16.3 | Acute symptomatic proximal deep vein thrombosis | KBG added to conventional treatment | Conventional treatment with thrombolysis and anticoagulant | The improvement rates of circumference difference between the affected and the normal limbs were significantly higher in the KBG group. | N/A |
Arakawa et al. (10) | DB-RCT | 204 | 52.3 ± 11 | Accessory symptoms of hypertension | OGT | Placebo | Efficacy was significantly higher in the OGT group based on the total score for the accessory symptoms of hypertension, especially hot flushes and facial suffusion. | None |
Nakamura et al. (11) | Crossover RCT | 10 | 57.6 ± 8.1 | Orthopedic hypotension related with diabetes mellitus | GRS | Placebo | The change of orthopedic systolic and diastolic pressure was significantly lower in the GRS group than in the placebo group. All patients complained of dizziness in the placebo group, but only 10% complained of the symptom in the GRS group. | N/A |
DB, double-blinded; GRS, goreisan; KBG, keishibukuryogan; OGT, orengedokuto; RCT, randomized controlled trial; SD, standard deviation; N/A, not assigned.