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. 2020 Jul 14;8:809. doi: 10.3389/fbioe.2020.00809

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Copyright © 2020 Han, Zhong, Hu, Liu, Liu and Ling.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional switch of common SNE gene network in different cancer cohort. (A) In total, we identified 17 non-specific cancer SNE core genes. (B) Non-specific core genes are directly involved in multiple cancer-related pathways, particularly multiple signaling pathways associated with DNA repair. (C) The non-specific core genes and their 1st ranking gene interactive network are also enriched in multiple pathways related to DNA repair. (D) In the TCGA-ESCA cohort data, multiple DNA repair functions were turnover before and after the tipping point. (E) The expression pattern of the gene interactions network was significantly reversed with heterogeneity across multiple cancer between before- and after- critical stage. In addition, some of the genes do not significant changes in expression level in pre-deterioration stage.