FIGURE 1.

Bioreactor platform and experimental plan. (A) Scheme of the connections among the bioreactor units: culture, stimulation, monitoring, and control units. (B) Lateral view of the bioreactor platform showing the chassis, the culture chamber, the sample holders, the position transducer, and the motor. (C) Top view of the sample holders within the culture chamber. (D) Top view of the bioreactor platform showing the load cell and, on the culture chamber lid, the sensors, the medium sampling/replacement port, the air filter, and the optical access. (E) Experimental plan of the ECT culture, showing the static pre-culture time up to day 5 (d5) and the following culture in either dynamic or static condition up to day 9 (d9).