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. 2020 Jul 15;8:491. doi: 10.3389/fcell.2020.00491

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Copyright © 2020 Chen, An, Huang, Xuan, Zhang, Ye, Luo, Xuan, He, Zheng and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Betaine ameliorates oxidative stress level at wound sites. (A) Immunofluorescence photomicrographs of heme oxygenase-1 (HO-1) in wounds for the control group, the free betaine solution (4 mg) group and BET@COL (2 mg, 4 mg, and 8 mg) treated group on day seven. Scale bars: 20 μm [10 μm in magnified images (a4–e4)]. (B) Quantitative result of immunofluorescence, n = 5. BET, betaine; COL, collagen. Statistical differences were performed using ANOVA. **p < 0.01, *p < 0.05, compared to control group.