Table 1.

18 genes which were associated with pathways involved in metastasis and relative KEGG pathway, and DMFS analysis.

	Gene name	KEGG Pathway enrichment analysis	DMFS analysis HR (P)
1	FZD4	Wnt signaling pathway, Hippo signaling pathway, signaling pathways regulating pluripotency of stem cells, melanogenesis, HTLV-I infection, pathways in cancer, proteoglycans in cancer, basal cell carcinoma	0.47 (0.034)
2	UTS2R	Neuroactive ligand-receptor interaction	1.42 (0.350)
3	PTPRJ	Adherens junction	1.66 (0.048)
4	CPSF3	mRNA surveillance pathway	0.50 (0.088)
5	MTHFD2L	One carbon pool by folate, Metabolic pathways	1.77 (0.035)
6	MYH11	Tight junction	2.06 (0.033)
7	LPGAT1	Glycerophospholipid metabolism	1.57 (0.270)
8	LAPTM4B	Lysosome	1.36 (0.230)
9	IL1R1	MAPK signaling pathway, cytokine–cytokine receptor interaction, NF-kappa B signaling pathway, osteoclast differentiation, hematopoietic cell lineage, inflammatory mediator regulation of TRP channels, amoebiasis, HTLV-I infection	1.59 (0.160)
10	COL3A1	PI3K-Akt signaling pathway, focal adhesion, ECM-receptor interaction, platelet activation, protein digestion and absorption, amoebiasis	1.74 (0.041)
11	ALG10B	N-Glycan biosynthesis, metabolic pathways	2.14 (0.033)
12	GMPPB	Fructose and mannose metabolism, amino sugar and nucleotide sugar metabolism, metabolic pathways	1.43 (0.190)
13	RNASEH1	DNA replication	1.53 (0.100)
14	UBE4B	Ubiquitin mediated proteolysis, protein processing in endoplasmic reticulum	2.46 (0.007)
15	NCOA1	Thyroid hormone signaling pathway	1.47 (0.200)
16	SNRPE	Spliceosome	1.45 (0.160)
17	TGM2	Huntington's disease	0.54 (0.043)
18	FDFT1	Steroid biosynthesis, metabolic pathways, biosynthesis of antibiotics	1.28 (0.340)