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. 2020 Jul 14;14:39. doi: 10.3389/fnana.2020.00039

Figure 1.

Figure 1

Tuberous sclerosis complex (TSC) histopathology. (A) Midsagittal section of an adult human brain MRI with a model cortical tuber (outlined in red) and subependymal giant cell astrocytoma (SEGA; outlined in green). Modified from the Allen Brain Atlas, The Brain Explorer 2 software. (B) Coronal section of an adult human brain with a model cortical tuber (outlined in red) and SEGA (outlined in green). Modified from the Allen Brain Atlas, The Brain Explorer 2 software. (C,D) Schematic of cortical tuber (C) and healthy (D; Mühlebner et al., 2016b) cortical tissue demonstrating neurons (blue nuclei), astrocytes (pink nuclei), microglia (gray), and giant cells (light green, tuber only). Note that cytomegaly, dysmorphic neurons, mislamination, gliosis, giant cells, and immune cell infiltration are features of “hot” epileptic cortical tubers. (E,F) Schematic of SEGA (Lopes et al., 1996) and healthy VZ-subventricular zone (SVZ) tissue (Sanai et al., 2011) from children demonstrating neurons (blue nuclei), astrocytes (pink nuclei), microglia (gray), ependyma (yellow), neural stem cells (NSCs; orange) and giant cells (light green, SEGA only).