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The general findings of brain metabolites variations reported in the MRS studies conducted in HSP and selected for the present review. Presentation of the anatomic regions sampled for spectroscopy and the metabolic pattern compared to healthy controls. NAA, N-acetyl-aspartate; Cho, Choline; mI, myoinositol; Cr, creatine; Lip, lipids; Lac, lactate; WM, white matter; F, frontal; P, parietal; O, occipital; GM, gray matter; CSF, cerebro-spinal fluid; −, reduced; +, increased.
