TABLE 1.

Oligosaccharides with altered serum IgG reactivity in IBD patients.

Increased IgG reactivity in CD			Increased IgG reactivity in UC
Composition	logFC	P-value	Composition	logFC	P-value
H3N1S1	4.19	0.01	H4N2F3	4.40	0.00
H4N2F3	4.02	0.00	H3N1F1S1	3.70	0.02
H6N4F4/H7N5F2	3.75	0.00	H3N1F1 (LNnFP V)	3.33	0.02
H5N3F3	3.67	0.00	H5N3F2	3.22	0.01
H4N2F2	3.67	0.02	H4N2F2	3.22	0.05
H4N2F3	3.49	0.01	H6N4F3	3.10	0.04
H4N2F2S1	3.44	0.01	H5N3F2	2.92	0.03
H7N5F3/H8N6F2	3.39	0.01	H4N2F1S1	2.78	0.03
H6N4F2/H7N5F1	3.34	0.02
H7N5	3.20	0.01
H4N2F1S1	3.17	0.01
H4N2F1S1	3.10	0.05
H5N3F1	3.07	0.03
H4N2F3	2.92	0.02
unknown	2.82	0.01
H5N3F3	2.81	0.05
H5N3F1S1	2.78	0.03
H4N2F3	2.76	0.04
H4N2F2	2.74	0.03
H4N2F2	2.70	0.05
H3N1F2	2.55	0.05
H5N3F2	2.54	0.04
H9N7F4	2.44	0.05
H10N8F4	2.36	0.04
H2F1 (3-FL)	2.14	0.05
H4N2F2S1	2.10	0.03
Decreased IgG reactivity in CD			Decreased IgG reactivity in UC
Composition	logFC	P-value	Composition	logFC	P-value
H5N3F3S1/H6N4F2S1	2.66	0.02	H5N3F1S1	3.91	0.00
H5N3F1S1	2.54	0.03	H5N3F1S1	3.07	0.01
H3N1S1 (LSTb)	2.51	0.03	H5N3F2S1	3.05	0.01
H6N4S1	2.11	0.02	H5N3F2S2	2.83	0.03
H5N3F1S1	2.03	0.04	H6N4S1	2.72	0.01
			H6N4F1S1	2.46	0.00

H, hexose; N, N-acetyl-hexosamine; F, fucose; S, sialic acid; 3-FL, 3-Fucosyllactose; LNFP V, Lacto-N-fucopentaose V; LNnFP V, Lacto-N-neofucopentaose V; LNnT, Lacto-N-neotetraose; LST b, Sialyllacto-N-tetraose b.