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. 2020 Jul 14;10:1143. doi: 10.3389/fonc.2020.01143

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Copyright © 2020 Li, Yang, Li, Bin, Sun, Huang, Yang, Shan, Gu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HER2-positive breast cancer cells induced expansion of anti-HER2 CAR-T cells can be further enhanced with the addition of anti-PD1 antibody. Blank T cells or anti-HER2 CAR-T cells were co-cultured with (A) 4T1 or (B) 4T1-Luc-HER2 cells in the absence or presence of anti-PD1 antibody at an effector: target ratio of 4:1 for 24, 48 or 72 h. Viable cells were counted by trypan blue exclusion each day. The mean values from three different experiments were presented. CAR-T group was compared with blank T group, **P < 0.01 and ***P < 0.001; or CAR-T plus anti-PD1 group was compared with blank T plus anti-PD1 group, ▴▴▴P < 0.001; or CAR-T group plus anti-PD1 group was compared with CAR-T group, ^#P < 0.05.