Table 1.

Characteristics of CD8⁺ T cell donors analyzed by microRNA microarray.

Sample ID	Diagnosis	Smoker	Disease duration	MTX, mg/w	cDMARD	Biologics	Prednisolone, mg/d
1	RA	No	5	10	MTX	TNFi	NA
	RA	No	8	25	MTX	TNFi	NA
	RA	No	9	0	SLZ	TNFi	NA
2	RA	Yes	23	15	MTX	CTLA4	NA
	RA	Yes	5	10	MTX	TNFi	NA
3	HC	Yes	NA	0	No	No	NA
	HC	Yes	NA	0	No	No	NA
4	HC	No	NA	0	No	No	NA
	HC	No	NA	0	No	No	NA
5	RA	Yes	31	25	MTX	CTLA4	NA
6	HC	No	NA	0	No	No	NA
7	RA	No	13	20	MTX	aCD20	NA
8	HC	Yes	NA	0	No	No	NA
9	RA	Yes	10	25	MTX	TNFi	NA
10	HC	No	NA	0	No	No	NA
11	RA	Yes	11	25	SLZ+PQ	No	5
	RA	Yes	44	0	No	TNFi	5
12	HC	Yes	NA	0	No	No	NA
13	RA	No	2	15	MTX	TNFi	NA
	RA	No	22	12.5	MTX	TNFi	NA
14	RA	Yes	7	0	SLZ	TNFi	NA
15	RA	Yes		20	MTX	TNFi	NA
16	RA	No	11	20	MTX	No	NA

The CD8⁺ T cells from 23 donors were pooled into 16 samples based on diagnosis and smoke status. RA, patients with rheumatoid arthritis; HC, healthy controls; MTX, methotrexate; SLZ, sulfasalazine; PQ, Plaquenil; TNFi, TNFa inhibitors (infliximab, golimumab, etanercept); CTLA4, CTLA4-immunoglobulin fusion protein (abatacept); aCD20, anti-CD20 antibodies (rituximab); RNA, ribonucleic acid; NA, not applicable. Sample 9 and 10 are shaded in gray because they were excluded from the analysis.