Table 1.
Patient and tumor characteristics.
| Characteristics | MGMT promoter | ||||||
|---|---|---|---|---|---|---|---|
| All n % | Methylated n % | Unmethylated n % | p-value | ||||
| 326 | 100 | 177 | 54.3 | 149 | 45.7 | ||
| Sex | 0.006 | ||||||
| Male | 206 | 63.2 | 100 | 48.5 | 106 | 51.5 | |
| Female | 120 | 36.8 | 77 | 64.2 | 43 | 35.8 | |
| Age, Years | 0.122 | ||||||
| ≤ 65 | 162 | 49.7 | 81 | 50.0 | 81 | 50.0 | |
| >65 | 164 | 50.3 | 96 | 58.5 | 68 | 41.5 | |
| Mean, years (SD) | 63.8 (10.5) | 64.2 (10.9) | 63.3 (10.1) | 0.453 | |||
| KPS | 0.748 | ||||||
| ≤ 70 | 119 | 36.5 | 66 | 55.5 | 53 | 45.5 | |
| > 70 | 207 | 73.5 | 111 | 53.6 | 96 | 46.4 | |
| Mean (SD) | 79.2 (12.4) | 78.8 (12.2) | 79.7 (12.6) | 0.480 | |||
| Pre-operative Tumor Volume, Median cm3 (IQR) | |||||||
| CE | 34.9 (15.5–55.8) | 30.7 (13.8–52.5) | 39.9 (17.1–26.2) | 0.050 | |||
| NCE | 72.1 (29.4–127.5) | 78.1 (27.8–133.8) | 64.9 (32.3–113.4) | 0.249 | |||
| Residual Tumor Volume, Median cm3 (IQR) | |||||||
| CE | 5.0 (1.41–12.3) | 6.1 (1.8–12.5) | 3.8 (1.1–12.0) | 0.097 | |||
| NCE | 39.7 (18.3–73.7) | 42.2 (17.1–79.6) | 36.5 (20.4–64.2) | 0.699 | |||
| Maximal CE Resection | 0.213 | ||||||
| Yes | 61 | 18.7 | 27 | 44.3 | 34 | 55.7 | |
| No | 187 | 57.4 | 105 | 56.2 | 82 | 43.8 | |
| Biopsy | 78 | 23.9 | 45 | 57.7 | 33 | 42.3 | |
| Median EOR (IQR) | 83.4 (14.2-94.8) | 79.6 (0-91.9) | 88.0 (25-7-96.0) | 0.075 | |||
| NCE Resection | 0.609 | ||||||
| ≥30% | 156 | 47.9 | 87 | 55.8 | 69 | 44.2 | |
| <30% | 170 | 52.1 | 90 | 52.9 | 80 | 47.1 | |
| Median EOR (IQR) | 27.1 (0–57.1) | 28.7 (0–58.4) | 25.8 (0–55.0) | 0.948 | |||
| Adjuvant Therapy | 0.294 | ||||||
| No therapy | 61 | 18.7 | 38 | 62.3 | 23 | 37.7 | |
| Radio- or chemotherapy alone | 56 | 17.2 | 27 | 48.2 | 29 | 51.8 | |
| Chemoradiation | 209 | 64.1 | 112 | 58.4 | 97 | 41.6 | |
| Overall Patient Outcome | |||||||
| Median overall survival (95% CI) | 309 (278.0–340.0) | 334 (266.8–401.2) | 305 (275.2-334.8) | 0.003 | |||
| Median progression-free survival (95% CI) | 184 (159.3–208.7) | 174 (131.2–216.8) | 190 (162.0–218) | 0.053 | |||
MGMT, methylguanine methyltransferase; SD, standard deviation; CE, contrast enhancement; NCE, non contrast enhancement; EOR, extent of resection; IQR, Inter Quartile Range; CI, Confidence interval.