Table 2.
Cox proportional hazards models for overall survival and progression-free survival.
| Variable | Median days, 95%CI | Overall survival | Median days, 95%CI | Progression-free survival | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Univariable | Multivariable | Univariable | Multivariable | |||||||
| HR, 95% CI | P-Value# | Adjusted HR, 95% CI | P-Value§ | HR, 95% CI | P-Value# | Adjusted HR, 95% CI | P-Value§ | |||
| Age, years | ||||||||||
| >65 | 259, 191–327 | a | 144, 114–175 | a | ||||||
| ≤ 65 | 358, 311–405 | 0.64, 0.51–0.80 | <0.0001 | 0.63, 0.49–0.81 | <0.0001 | 216, 181–251 | 0.70, 0.56–0.89 | 0.003 | 0.82, 0.64–1.06 | 0.123 |
| KPS | ||||||||||
| ≤ 70 | 199, 142–256 | a | 120, 91–149 | a | ||||||
| >70 | 369, 319–419 | 0.59, 0.47–0.74 | <0.0001 | 0.92, 0.71–1.19 | 0.545 | 223, 181–265 | 0.51, 0.40–0.65 | <0.0001 | 0.59, 0.45–0.77 | <0.0001 |
| MGMT Promoter | ||||||||||
| Unmethylated | 305, 275–335 | a | b | 190, 162–218 | a | b | ||||
| Methylated | 334, 267–401 | 0.72, 0.57–0.90 | 0.004 | 174, 131–217 | 0.79, 0.62–1.00 | 0.054 | ||||
| Adjuvant Therapy | ||||||||||
| None | 65, 46–84 | a | 47, 38–56 | a | ||||||
| Radiotherapy or chemotherapy | 217, 146–288 | 0.38, 0.26–0.55 | <0.0001 | 0.29, 0.19–0.43 | <0.0001 | 129, 107–151 | 0.23, 0.15–0.36 | <0.0001 | 0.22, 0.14–0.35 | <0.0001 |
| Chemoradiation | 423, 367–479 | 0.14, 0.11–0.19 | <0.0001 | 0.13, 0.09–0.19 | <0.0001 | 254, 222–287 | 0.09, 0.06–0.13 | <0.0001 | 0.09, 0.06–0.14 | <0.0001 |
| Pre-operative CE Tumor Volume | ||||||||||
| smaller per cm3 | 0.92, 0.83–1.01 | 0.094 | 0.85, 0.75–0.95 | 0.007 | 0.94, 0.85–1.04 | 0.239 | 0.99, 0.88–1.11 | 0.860 | ||
| Maximal CE Resection | * | * | ||||||||
| Biopsy | 153, 106–200 | a | 100, 87–113 | a | ||||||
| No | 309, 278–340 | 0.79, 0.60–1.04 | 0.090 | 0.87, 0.61–1.23 | 0.415 | 190, 170–210 | 0.80, 0.61–1.05 | 0.109 | 1.25, 0.89–1.81 | 0.228 |
| Yes | 441, 321–560 | 0.51, 0.36–0.72 | <0.0001 | 0.58, 0.39–0.87 | 0.009 | 272, 210–334 | 0.59, 0.42–0.85 | 0.004 | 0.97, 0.63–1.50 | 0.898 |
| NCE Resection | * | * | ||||||||
| <30% | 266, 213–319 | a | 155, 104–206 | a | ||||||
| ≥30% | 344, 304–385 | 0.72, 0.58–0.91 | 0.005 | 0.71, 0.53–0.93 | 0.014 | 203, 166–240 | 0.82, 0.65–1.03 | 0.087 | 0.87, 0.65–1.15 | 0.325 |
a
Reference group.
b
Proportional hazard assumption for MGMT was violated, therefore multivariable Cox regression model was stratified for MGMT.
HR, Hazard ratio; MGMT, methylguanine methyltransferase, CI Confidence Interval.
*
for MGMT-stratified median overall survival, see Figure 1.
#
entry significance threshold of p < 0.1.
§
significance threshold of p < 0.05.