Table 1.
Screening for the anti-angiogenic activity of synthesized BET inhibitors using the chick embryo CAM model.
| Compounds | 1 | 2 | 3 | 4 | 5 | 6 | Positive Ratio |
|---|---|---|---|---|---|---|---|
| Egg number | |||||||
| DMSO | + | + | + | - | |||
| (+)-JQ1(1) | +++ | +++ | ++ | ++ | + | ++ | 5/6 |
| ZL0454(2) | +++ | ++ | +++ | ++ | + | +++ | 5/6 |
| MS436(3) | ++ | +++ | +++ | +++ | + | 4/5 | |
| ZL0164(4) | - | - | ++ | ++ | + | 2/5 | |
| ZL0452(5) | - | + | ++ | + | 1/4 | ||
| ZL0453(6) | + | - | ++ | + | + | 1/5 | |
| ZL0513(7) | ++ | ++ | +++ | + | ++ | 4/5 | |
| ZL0518(8) | ++ | - | - | - | ++ | + | 1/3 |
| ZL0519(9) | ++ | - | ++ | +++ | 3/4 | ||
| ZL0520(10) | + | - | ++ | + | - | 1/5 | |
| ZL0549(11) | ++ | - | ++ | +++ | 3/4 | ||
| ZL0586(12) | ++ | + | + | ++ | + | 2/5 | |
| ZL0588(13) | - | ++ | ++ | - | + | 2/5 | |
| ZL0589(14) | ++ | - | - | ++ | + | 2/5 | |
| ZL0593(15) | ++ | ++ | + | ++ | - | 3/5 | |
| HJC5100(16) | + | - | + | - |