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. 2020 Jul 10;11:765. doi: 10.3389/fgene.2020.00765

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Copyright © 2020 Khan, Sany, Islam and Islam.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enrichment analysis and comparison between host miRNA targets induced by SARS-CoV and SARS-CoV-2 infections. (A) Heatmap representation of enriched pathways involved in host defense obtained using Funrich software. (B) Enriched pathways that might act as proviral mechanisms obtained using Funrich software. Enrichment of downregulated host miRNA target genes in SARS-CoV and SARS-CoV-2 using gitools. (C) GO Biological Process module. (D) GO Molecular Function module. (E) KEGG pathway modules. The significance of enrichment in terms of adjusted p-value (<0.05) is represented in a color-coded P-value scale for all heatmaps. Color toward red indicates higher significance and color toward yellow indicates less significance, while gray means non-significant. Only selected significant enriched terms are shown.