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Lipid A variants obtained by chemical and enzymatic modification. MPLA is obtained by chemical hydrolysis of the C-1 phosphate of the Salmonella Minnesota LPS. BECC (Bacterial Enzymatic Combinatorial Chemistry) allows for the selective modification of single or multiple fatty acid chains or phosphates (depicted by colors associated to involved enzymes) in order to obtain compounds such as BECC438 with high purity.
