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. 2020 Jul 8;7:96. doi: 10.3389/fnut.2020.00096

Figure 3.

Figure 3

Inhibition of 15-Pgdh activity in Se-A mice exacerbates infection. (A) Representative western immunoblot and (B) quantification of Cox2 in the colonic extracts of Se-D, Se-A, and Se-S mice on day 11 PI. (C) Representative western immunoblot and (D) quantification of 15-Pgdh from colonic extracts of Se-D, Se-A, and Se-S mice on day 11 PI. (E) Shedding curve of C. rodentium infected Se-A mice treated with vehicle control or CAY10397. (F) Colon length of Se-A mice treated with control or CAY10397 on day 11 PI. (G) Colon length of Se-A mice treated with control or CAY10397 at day 30 PI. (H) Colonic crypt length of Se-A mice treated with control or CAY10397 on day 11 PI. Data indicate mean ± SEM of two independent experiments and n = 3-6 mice/group; one-way ANOVA (D) two-way ANOVA (E) unpaired t-test (F–H). *P < 0.05, **P < 0.01, n.s., not significant.