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. 2020 Jul 8;7:96. doi: 10.3389/fnut.2020.00096

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Copyright © 2020 Nettleford, Zhao, Qian, Herold, Arner, Desai, Amin, Xiong, Singh, Carlson and Prabhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activity of 15-Pgdh in Se-A mice is required for maintenance of the epithelial barrier integrity. mRNA expression of (A) Cox2, (B) Mpges1, (C) Hpgds and (D) Zo-1 in the colon of Se-A mice treated with control or CAY10397 on day 11 PI. (E) Representative western immunoblot and (F) quantification of Zo-1 in the colonic extracts of Se-A mice treated with control or CAY10397 on day 11 PI. (G) FITC concentration in the serum of Se-A mice treated with control or CAY10397 on day 11 PI. Data indicate mean ± SEM of n = 4-8 mice/group, unpaired t-test (A,D,F,G) ^*P < 0.05, ^***P < 0.001, n.s., not significant.