Table 2.

Verification of previously reported LGG prognostic predictors in OSlgg.

Gene symbol	Biomarker name	Clinical survival terms	In OSlgg					In reference					Worse prognosis (expression)	References
			Cut-off	p value	HR	95%CI	Case	Cut-off	p value	Case	Detection level	Validation
CDH2	N-cadherin	OS	Upper 25%	<0.0001	2.3827	1.6847-3.3699	525		OS: p < 0.001	343	Protein	Yes, IHC assay	Higher	(19)
		RFS		0.0026	1.7159	1.2069-2.4396
EGFR	EGFR	OS	Upper 25%	2e-04	1.9435	1.3703-2.7565	525	Upper n = 7 /Lower n = 18	OS: p < 0.01	25	Protein	Yes, IHC assay	Higher	(20, 21)
		RFS		0.0434	1.4379	1.0108-2.0453
IDH1	IDH1	OS	Upper 50%	0.0024	1.7174	1.2118-2.4338	525	WT n = 108 /MT n = 310	OS: p = 0.015	418	DNA pyrosequencing		Higher	(22)
		RFS		0.0501	1.3913	0.9999-1.9359
VEGFA	VEGFA	OS	Upper 25%	<0.0001	2.5754	1.8074-3.6696	525	Upper n = 39 /Lower n = 35	OS: p = 0.002	74	Protein	Yes, IHC assay	Higher	(23, 24)
		RFS		<0.0001	2.1336	1.4857-3.0641
		PFS	Upper 25%	0.0296	1.604	1.0478-2.4555	195
NES	nestin	OS	Upper 25%	0.0178	1.5426	1.0779-2.2076	525	Upper n = 25 /Lower n = 25	OS: p = 0.0004	50	Protein	Yes, IHC assay	Higher	(25–27)
		RFS		0.02	1.5177	1.0679-2.1569
BIRC5	survivin	OS	Upper 30%	<0.0001	2.5472	1.8055-3.5937	525	Upper n = 13 /Lower n = 8	OS: p = 0.007	21	Protein	Yes, IHC assay	Higher	(28)
		RFS		<0.0001	1.9996	1.437-2.7824
		PFS	Upper 25%	0.0156	1.6915	1.1047-2.5899	195
PCNA	PCNA	OS	Upper 25%	<0.0001	2.7723	1.9575-3.9263	525		OS: p = 0.0009	85	Protein	Yes, IHC assay	Higher	(29)
		RFS		6e-04	1.8521	1.3048-2.629
MKI67	Ki-67	OS	Upper 30%	<0.0001	2.4146	1.7159-3.3978	525	Upper n = 128 /Lower n = 52	OS: p = 0.047	180	Protein	Yes, IHC assay	Higher	(30–32)
		RFS		<0.0001	2.1909	1.5759-3.0458
CDKN1B	p27	OS	Lower 50%	0.0073	1.6099	1.137-2.2793	525	Upper n = 30 /Lower n = 28	OS: p = 0.007	77	Protein	Yes, IHC assay	Lower	(21, 33, 34)
		RFS		0.0266	1.455	1.0444-2.027

WT, wild type; MT, mutation.