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. 2020 Jul 7;8:584. doi: 10.3389/fcell.2020.00584

FIGURE 1.

FIGURE 1

The physiological angiogenic cascade. Stable vessels (A) undergo a vascular permeability allowing extravasation of plasma proteins (B). MMPs degrate the extracellular matrix liberating growth factors (C). ECs proliferate and migrate (D) and undergo morphogenesis and assemble as lumen-bearing cords (E).