Figure 1:

A panel of representative MR images of a responding mouse prostate tumor following radiotherapy. Tumor volume and hyperpolarized (HP) [1-¹³C]lactate decreased after radiotherapy, while perfusion increased as shown using HP [¹³C]urea and dynamic contrast enhanced (DCE) MRI data. There was also an increase in the apparent diffusion coefficient (ADC) in this tumor, which is inversely correlated with cellularity. A frequency-calibration phantom for hyperpolarized ¹³C scans can be seen in the upper right corner of the images.