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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2020 Apr 25;107(5):887–896. doi: 10.1016/j.ijrobp.2020.04.022

Figure 2:

Figure 2:

Changes in normalized hyperpolarized (HP) 13C lactate, alanine, and urea following radiotherapy. There is an apparent decrease in lactate (A), an increase in alanine (B) and perfusion as seen in HP [13C]urea (C) among volume-decreasing tumors (responders) after radiotherapy. In contrast, there were no apparent changes among non-responders (Day 7 has 3 data points, with overlapping range bars and quantile bars). Multilevel regression analyses revealed a significant decrease in lactate, and significant increases in alanine and urea for responders, and these changes were significantly different from non-responders.