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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2020 Apr 25;107(5):887–896. doi: 10.1016/j.ijrobp.2020.04.022

Figure 3:

Figure 3:

Intratumoral dose-dependent changes in HP 13C pyruvate-to-lactate conversion. There were significant associations between radiation dose and normalized HP lactate (nLac) changes at all time points. Moreover, high-dose regions (10-14 Gy) showed a greater magnitude of decreases in nLac compared to low-dose regions (4-7 Gy), as early as Day 1. High-dose regions also showed significantly decreased nLac from baseline at Day 4 and Day 7, and intermediate-dose regions also showed significantly decreased nLac from baseline at Day 7 (*, P < .05; **, P < .01; ***, P < .001; black *, ** indicate significant difference between high- and low-dose; blue *, *** indicate significant change from baseline; IM = intermediate).