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. Author manuscript; available in PMC: 2020 Dec 29.
Published in final edited form as: Nat Immunol. 2020 Jun 29;21(8):857–867. doi: 10.1038/s41590-020-0705-6

Extended Data Fig. 3. Y. pestis YopM suppresses the pyrin inflammasome.

Extended Data Fig. 3

a,b, IL-1β measurements of culture supernatants of Mefv+/+ BMDMs primed with LPS, treated with or without C3 toxin, and infected with indicated MOI of WT (a) or ΔyopM (b) Y. pestis strains. Results are presented as mean ± s.e.m., for n=5 independent biological replicates. c, Immunoblot analysis of pyrin and pro-IL-1β in lysates of retroviral transduced U937 cells, expressing WT or indicated Ser to Ala mutant pyrin proteins. Data are representative of three independent experiments with similar results.