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. Author manuscript; available in PMC: 2020 Dec 29.
Published in final edited form as: Nat Immunol. 2020 Jun 29;21(8):857–867. doi: 10.1038/s41590-020-0705-6

Figure 8. FMF mutations confer an IL-1β-dependent survival advantage against Y. pestis infection in mice.

Figure 8

a, Kaplan-Meier survival curves for 12–16 week-old Mefv+/+ (n=19), MefvB30.2/B30.2 (n=17), MefvM680I/M680I (n=10), MefvM680I/M680IIl1r1−/− (n=10) and Mefv+/+Il1r1−/− (n=12) mice infected with approximately 100 or 150 CFU of Y. pestis by tail vein injection. *P = 0.0203 and ****P < 0.0001 (Gehan-Breslow-Wilcoxon test). b, IL-1β measurements of culture supernatants of Mefv+/+ or indicated FMF-KI BMDMs primed with LPS and infected with Y. pestis. Results are presented as mean ± s.e.m., for n=5 independent biological replicates. *P = 0.0159 and **P = 0.0079 (unpaired two-tailed t test) compared to WT.