Table 3.
Clinical and nutritional characteristics in the first 10 days of life in infants with and without LOS, NEC or death
| All infants (< 2000g) | VLBW infants (<1500g) | ELBW infants (<1000g) | ||||
|---|---|---|---|---|---|---|
| LOS, NEC or Death (n= 41) | No - Event (n=258) | LOS, NEC or (n=36) | No - Event (n=147) | LOS, NEC or Death (n=14) | No - Event (n=19) | |
| Clinical characteristics | ||||||
| Gender, female, n (%) | 14 (34.2) | 115 (44.67) | 14 (39.0) | 71 (48.3) | 5 (35.7) | 9 (47.4) |
| Birth weight in g, mean ± SD | 1169 ± 305 | 1448 ± 291 | 1090 ± 228 | 1245 ± 202 | 851 ± 98.0 | 842.7 ± 98.6 |
| Gestational age in weeks, mean ± SD | 29 ± 2.4 | 31 ± 2.6 | 29 ± 2.2 | 30 ± 2.5 | 27.4 ± 2.3 | 27.7 ± 2.5 |
| Small for gestational age, n (%) | 7 (17.1) | 71 (27.5) | 7 (19.4) | 41 (27.9) | 4 (28.6) | 6 (31.6) |
| Born by C-section, n (%) | 33 (80.5) | 210 (82.0) | 28 (77.8) | 120 (81.6) | 8 (57.1) | 11 (57.9) |
| Hospital, n (%) | ||||||
| Hospital 1 | 5 (12.2) | 66 (25.6) | 5 (14.0) | 36 (24.5) | 1 (7.14) | 3 (15.8) |
| Hospital 2 | 9 (22.0) | 132 (51.2) | 9 (25.0) | 80 (54.4) | 7 (50.0) | 12 (63.2) |
| Hospital 3 | 27 (65.9) | 60 (23.3) | 22 (61.1) | 31 (21.1) | 6 (42.9) | 4 (21.1) |
| Randomized to bovine LF, n (%) | 24 (58.5) | 127 (49.2) | 21 (58.3) | 75 (51.0) | 9 (64.3) | 10 (52.7) |
| Nutritional characteristics (days 4–10) | ||||||
| Cumulative intake of MOM in ml/kg, median (IQR) | 42 (11–146) | 176 (69–373) | 39 (10–139) | 106 (51–230) | 30 (12–42) | 44 (19–78) |
| % of human milk consumption, mean ± SD | 87.9 ± 28.5 | 75.3 ± 32.0 | 91.9 ± 24.0 | 82.6 ± 29.1 | 99.1 ± 3.5 | 91.9 ± 25.4 |
| Human LF concentration in mg/mL, mean ± SD | 15.28 ± 7.8* | 14.2 ± 8.2* | 13.9 ± 6.8† | 13.3 ± 7.4† | 15.6 ± 7.3§ | 15.8 ± 10.6§ |
| Cumulative human LF intake in mg/kg, median (IQR) | 621 (116–1971)* | 2335 (1051–4946)* | 542 (111–1694)† | 1285 (714–2936)† | 312 (111–621)§ | 531 (320–1225)§ |
| Average daily human LF intake in mg/kg, median (IQR) | 89 (17–282)* | 334 (150–707)* | 77 (16–242)† | 184 (102– 419)† | 45 (16–89)§ | 76 (46– 175)§ |
LOS, late onset sepsis; NEC, necrotizing enterocolitis; LF, lactoferrin; MOM, motheŕs own milk
*
n=240 infants (37 events and 203 no- events)
†
n=141 infants (31 events and 110 no- events)
§
n=25 infants (11 events and 14 no- events)