FIGURE 4.

Voluntary exercise selectively activates the AMPK pathway through adiponectin. Levels of phospho-p38MAPK^T180/Y182, phospho-AKT^S473, phospho-AMPK^T172, and phospho-Erk1/2^T202/Y204 following various treatments were quantified by ELISA. (A–D) In both strains, COR and exercise did not affect the expression of phospho-p38MAPK^T180/Y182 (A), phospho-AKT^S473 (B), or phospho-Erk1/2^T202/Y204 (D). However, exercise significantly raised the phospho-AMPK^T172 level in stressed WT, but not ADN-KO mice (C). Data are shown as means ± SD. n = 10 mice/group. *p < 0.05 by two-way ANOVA and Tukey’s post hoc test. N.S., non-significant; MAPK, mitogen-activated protein kinase; AKT, protein kinase B; AMPK, AMP-activated protein kinase; Erk, extracellular signal-regulated kinase.