TABLE 2.
The correlations between the performance in the MWM test and hippocampal mRNA levels.
| Cognitive phase | Age | Group |
Arc mRNA |
Syt1 mRNA |
||||
| CA1 | CA3 | DG | CA1 | CA3 | DG | |||
| r (p) | r (p) | r (p) | r (p) | r (p) | r (p) | |||
| Learning | 3 months | CON | 0.630 (0.18) | 0.401 (0.431) | −0.018(0.973) | 0.605 (0.203) | 0.547 (0.261) | −0.338(0.513) |
| swimming | CON + S | 0.514 (0.297) | 0.871(0.024)* | −0.186(0.724) | 0.418 (0.410) | 0.410 (0.420) | −0.232(0.658) | |
| distance | LPS | 0.922(0.009)** | 0.357 (0.487) | −0.616(0.193) | 0.884(0.019)* | 0.763 (0.077) | −0.096(0.857) | |
| LPS + S | 0.901(0.014)* | 0.367 (0.474) | −0.017(0.975) | 0.789 (0.062) | 0.882(0.020)* | −0.398(0.435) | ||
| 15 months | CON | −0.176(0.738) | −0.630(0.180) | −0.567(0.241) | 0.416 (0.412) | 0.601 (0.198) | 0.778 (0.069) | |
| CON + S | 0.953(0.003)** | 0.981(0.001)** | −0.049(0.926) | 0.982(0.000)** | 0.756 (0.082) | 0.321 (0.535) | ||
| LPS | 0.878(0.022)* | 0.800 (0.056) | −0.450(0.370) | 0.879(0.021)* | 0.938(0.006)** | −0.322(0.534) | ||
| LPS + S | 0.875(0.022)* | 0.825(0.043)* | 0.637 (0.174) | 0.925(0.008)** | 0.897(0.015)* | 0.496 (0.317) | ||
| Distance | 3 months | CON | −0.030(0.955) | −0.543(0.266) | −0.545(0.264) | 0.438 (0.385) | 0.480 (0.335) | 0.579 (0.228) |
| percentage | CON + S | −0.633(0.178) | −0.102(0.847) | 0.329 (0.524) | −0.813(0.049)* | 0.673 (0.143) | −0.243(0.643) | |
| in target | LPS | −0.867(0.025)* | −0.776(0.07) | 0.309 (0.551) | −0.851(0.032)* | −0.336(0.515) | 0.473 (0.343) | |
| quadrant | LPS + S | −0.975(0.001)** | −0.434(0.39) | −0.258(0.621) | −0.903(0.014)* | −0.973(0.001)** | −0.124(0.816) | |
| 15 months | CON | 0.163 (0.758) | 0.583 (0.224) | 0.349 (0.498) | −0.533(0.288) | −0.790(0.062) | −0.707(0.117) | |
| CON + S | −0.661(0.153) | −0.817(0.047)* | −0.324(0.531) | −0.783(0.066) | −0.992(0.000)** | −0.181(0.731) | ||
| LPS | −0.988(0.000)** | −0.933(0.007)** | 0.096 (0.856) | −0.967(0.002)** | −0.816(0.048)* | −0.164(0.756) | ||
| LPS + S | −0.918(0.01)** | −0.849(0.032)* | −0.315(0.544) | −0.966(0.002)** | −0.952(0.003)** | 0.045 (0.932) | ||
*P < 0.05; **P < 0.01. CA, cornu ammonis; DG, dentate gyrus; CON, untreated control group; LPS, lipopolysaccharide treatment group; S, group of mice exposed to stress.