Table 2.
Clinical characteristics of Covid-19 patients according to ICU admission and thrombotic events.
| Non-ICU patients | ICU patients | p | Patients without thrombotic events | Patients with thrombotic events | p | |
|---|---|---|---|---|---|---|
| N. | 150 | 32 | 147 | 35 | ||
| Age (years) | 63.6 ± 14.9 | 65.5 ± 12.3 | 0.501 | 62.5 ± 14.3 | 69.9 ± 13.7 | 0.006 |
| BMI (kg/m2) | 25.4 ± 4.0 | 29.1 ± 6.1 | 0.041 | 26.0 ± 4.2 | 27.9 ± 6.3 | 0.285 |
| Male sex | 55% | 84% | 0.002 | 60% | 60% | 1.000 |
| Arterial hypertension | 48% | 53% | 0.698 | 48% | 54% | 0.573 |
| Smokers | 15% | 19% | 0.804 | 15% | 18% | 0.800 |
| COPD | 10% | 22% | 0.075 | 12% | 14% | 0.773 |
| Diabetes | 19% | 28% | 0.337 | 20% | 26% | 0.488 |
| CAD | 17% | 37% | 0.016 | 16% | 40% | 0.004 |
| PAD | 11% | 16% | 0.540 | 8% | 26% | 0.007 |
| Heart failure | 9% | 31% | 0.002 | 10% | 23% | 0.052 |
| Atrial fibrillation | 8% | 12% | 0.489 | 8% | 11% | 0.515 |
| ACE-inhibitors/ARBs | 34% | 37% | 0.688 | 35% | 34% | 1.000 |
| SpO2 (%) | 96 [93-97] | 91 [85-97] | 0.034 | 96 [93-97] | 94 [88-97] | 0.143 |
| P/F ratio | 352 [293-421] | 171 [130-257] | <0.001 | 352 [281-414] | 217 [158-387] | 0.032 |
| hs-CRP (mg/L) | 45 [14-98] | 150 [70-263] | <0.001 | 45 [16-108] | 127 [48-203] | 0.004 |
| D-dimer (ng/ml) | 1146 [537–2026] | 4610 [1628–4800] | < 0.001 | 1090 [555–1974] | 4474 [1657–4800] | < 0.001 |
| sNox2 (pg/ml) | 32 [24-42] | 38 [29-51] | 0.026 | 32 [23-43] | 36 [30-48] | 0.044 |
Legend: ACE: angiotensin converting enzyme, ARBs: angiotensin receptor blockers, BMI: body mass index, CAD: coronary heart disease, COPD: chronic obstructive pulmonary disease, hs-CRP: high sensitivity C reactive protein, P/F: PaO2/Fi02 ratio, sNox2-dp: serum Nox2-derived peptide, SpO [2]: oxygen saturation. Differences between percentages were assessed by Fisher exact tests. All continuous variables were tested for normality with the Shapiro-Wilk test. Student unpaired t-test was used for normally distributed continuous variables (expressed as mean ± SD). Mann-Whitney U test was used for not-normally distributed continuous variables (expressed as median [interquartile range]).