Table 2.
Associations between the concentration and clearance of small, middle molecules solute and cognitive function at baseline by multivariable linear regression analysis in 222 patients (95% confidence interval for β coefficients as shown)
| 3MS score# | Trail A, s | Trail B, s | Immediate memory score# | Delayed memory score# | Visuospatial skill score# | Language skill score# | |
|---|---|---|---|---|---|---|---|
| Serum urea (mmol/l) | − 0.09 (− 0.30, 0.12) | − 1.43 (− 3.02, 1.57) | − 1.32 (− 3.93, 1.28) | − 0.23 (− 0.67, 0.20) | − 0.14 (− 0.48, 0.21) | 0.19 (− 0.41, 0.79) | 0.03 (− 0.33, 0.38) |
| Serum creatinine (μmol/l) | − 0.001 (− 0.005, 0.003) | 0.00 (− 0.03, 0.03) | − 0.04 (− 0.09, 0.02) | − 0.006 (− 0.01, 0.002) | − 0.003 (− 0.009, 0.004) | − 0.004 (− 0.02, 0.008) | 0.003 (− 0.004, 0.01) |
| Serum B2M (mg/l) | − 0.14 (− 0.59, 0.33) | 1.03(− 2.44, 4.50) | − 0.08 (− 5.73, 5.57) | 0.23 (− 0.71, 1.17) | 0.31 (− 0.44, 1.05) | − 0.54 (− 0.18, 0.76) | 0.12 (− 0.66, 0.89) |
| Total Kt/V | 2.43 (− 0.41, 5.27) | − 1.52 (− 22.7, 19.7) | 5.16 (− 29.70, 40.01) | 4.19 (− 1.72, 10.1) | 6.19 (1.62, 10.8)** | 4.83 (− 3.12, 12.8) | − 0.05 (− 4.79, 4.69) |
| Renal Kt/V | − 0.36 (− 2.84, 2.11) | − 10.5 (− 28.8, 7.84) | 2.95 (− 27.49, 33.39) | 0.77 (− 4.37, 5.90) | 1.08 (− 2.95, 5.11) | 6.87 (0.04, 13.7) | − 0.33 (− 4.43, 3.77) |
| Peritoneal Kt/V | 1.56 (− 0.52, 3.65) | 6.71 (− 8.84, 22.27) | 0.69 (− 24.86, 26.24) | 1.70 (− 2.64, 6.04) | 2.56 (− 0.84, 5.96) | − 2.33 (− 8.16, 3.49) | 0.21 (− 3.26, 3.68) |
| Total Ccr (l/w/1.73 m2) | 0.007 (− 0.06, 0.08) | − 0.17 (− 0.69, 0.36) | − 0.07 (− 0.92, 0.79) | 0.05 (− 0.09, 0.19) | 0.07 (− 0.05, 0.18) | 0.16 (− 0.03, 0.36) | − 0.03 (− 0.15, 0.09) |
| Renal Ccr (l/w/1.73 m2) | − 0.01 (− 0.07, 0.04) | − 0.23 (− 0.63, 0.17) | 0.05 (− 0.62, 0.71) | − 0.02 (− 0.09, 0.13) | 0.01 (− 0.08, 0.10) | 0.15 (− 0.001, 0.29) | − 0.02 (− 0.11, 0.07) |
| Peritoneal Ccr (l/w/1.73 m2) | 0.04 (− 0.04, 0.13) | 0.32 (− 0.30, 0.95) | − 0.20 (− 1.23, 0.83) | 0.04 (− 0.14, 0.21) | 0.07 (− 0.07, 0.21) | − 0.12 (− 0.36, 0.11) | 0.009 (− 0.13, 0.15) |
| Total B2M clearance (l/w/1.73 m2) | 0.25 (0.04, 0.46)* | − 2.55 (− 3.86, − 1.23)*** | − 1.17 (− 3.88, 1.53) | 0.13 (− 0.25, 0.51) | − 0.02 (− 0.31, 0.28) | 0.02 (− 0.49, 0.53) | 0.06 (− 0.24, 0.37) |
| Renal B2M clearance (l/w/1.73 m2) | − 0.29 (− 0.71, 0.14) | − 1.25 (− 4.40, 1.89) | 0.12 (− 5.14, 5.38) | − 0.37 (− 1.25, 0.49) | 0.06 (− 0.62, 0.75) | 0.59 (− 0.58, 1.78) | 0.07 (− 0.63, 0.78) |
| Peritoneal B2M clearance (l/w/1.73 m2) | 0.21 (0.02, 0.41)* | − 2.50 (− 3.92, − 1.09)*** | − 0.80 (− 3.01, 1.40) | 0.26 (− 0.15, 0.66) | − 0.02 (− 0.33, 0.30) | − 0.08 (− 0.63, 0.47) | 0.05 (− 0.28, 0.38) |
All models were adjusted for age, dialysis vintage, education level, the presence of diabetes, serum albumin, hs-CRP, hyponatremia and mean arterial pressure
Kt/V urea clearance per week, Ccr creatinine clearance per week, B2M beta-2 microglobulin
#The higher scores for 3MS, immediate and delayed memory, language and visuospatial function meant the better performance. The higher score for trails A meant the worse executive function. T scores of immediate and delayed memory, language and visuospatial function were applied in above analyzes
*P < 0.05, **P < 0.01, ***P < 0.001 for all β coefficients