Table 3.
Interregional correlation analysis of hypometabolic clusters and putative regions implicated in FOP
| FOP+ subjects (n = 9) | FOP- subjects (n = 16) | |
|---|---|---|
| Left Middle Frontal |
L middle Frontal (autocorrelation) L superior Frontal R Superior Temporal R Insula L angular R lingual R Cerebellum (8th hemisphere) |
L middle Frontal (autocorr.) L middle Temporal R Supramarginal and middle Temporal R Cerebellum (8th hem.) |
| L Superior Frontal |
L superior Frontal (autocorr.) L Superior Temporal R and L Insula R and L Precuneus R lingual |
L and R Superior and Middle Frontal (autocorr.) L and R Inferior Temporal L and R angular and supramarginal R Cerebellum (8th hem.) |
| L Precentral |
L middle Frontal L Precentral (autocorr.) L anterior Cingulate L Rolandic Operculum R and L Superior Parietal R Putamen |
L and R Precentral (auto) L and R middle Frontal R superior Frontal L Rectus L inferior Temporal L Superior Parietal |
| L Precuneus |
L Superior Frontal R Precentral L middle Temporal R Insula L and R Precuneus (autocorr.) L Putamen |
R superior Frontal L middle Frontal L and R Precuneus and superior Parietal (autocorr.) |
| L Superior Parietal |
L Superior Frontal R middle Temporal pole R Superior Parietal L inferior and superior Parietal (autocorr.) |
R superior Frontal L superior Parietal and Precuneus (autocorr.) |
| L angular |
L angular, supramarginal and middle Temporal (autocorr.) R Precuneus R Supramarginal R Putamen |
Middle Temporal, angular and inferior Parietal (autocorr.) |
| L supramarginal |
L Precentral R Insula L angular, supramarginal, superior and middle Temporal (autocorr.) R Precuneus R Cerebellum (8th hem.) |
L Inferior and superior Frontal R middle and superior Orbitofrontal R middle Temporal R Cerebellum (8th hem.) |
| L Superior Temporal |
L Superior and middle Temporal (autocorr.) R Insula R Cerebellum (8th hem.) |
L and R middle and superior Temporal (autocorr.) R Cerebellum (8th hem.) |
| L Temporoparietal junction |
L Superior Frontal L Precentral R Insula L angular, supramarginal and Superior Temporal (autocorr.) R Precuneus R Cerebellum (8th hem.) |
L and R middle Frontal L middle Temporal, angular and supramarginal (autocorr.) R supramarginal |
Interregional Correlation Analysis (IRCA) of the five hypometabolic FDG PET clusters in subgroup with FOP, as well as putative areas implicated in FOP (left temporoparietal junction and adjacent regions) used as seeds. Positive correlation, uncorrected p < 0.001, extent threshold >20 voxels. L = left, R = right