Table 3.
Baseline predictors of time to first hypocalcemia episode in the first 12 months after cinacalcet initiation
| Characteristics | Any hypocalcemia vs no hypocalcemia | ||
|---|---|---|---|
| No. of hypocalcemia events/total no. of subjects (%) | Hazard ratio (95% CI) | p value | |
| Geographical area | 0.01 | ||
| Iberian Peninsulaa | 513/750 (68.4) | References | |
| Eastern Europeb | 56/81 (69.1) | 1.22 (0.87, 1.70) | |
| Western Europec | 41/74 (55.4) | 0.65 (0.46, 0.90) | |
| Catheter vascular access | <0.001 | ||
| No | 434/680 (63.8) | References | |
| Yes | 158/195 (81.0) | 1.59 (1.32, 1.92) | |
| Missing information | 18/30 (60.0) | 0.91 (0.52, 1.57) | |
| Haemoglobin [g/dL] | 0.03 | ||
| ≥ 12 | 306/436 (70.2) | References | |
| 10–< 12 | 276/423 (65.2) | 0.87 (0.74, 1.03) | |
| < 10 | 28/46 (60.9) | 0.61 (0.41, 0.91) | |
| Serum albumin [g/L] | 0.003 | ||
| Q4 | 98/160 (61.3) | References | |
| Q3 | 155/258 (60.1) | 1.07 (0.83, 1.37) | |
| Q2 | 167/222 (75.2) | 1.46 (1.13, 1.87) | |
| Q1 | 156/213 (73.2) | 1.47 (1.14, 1.91) | |
| Missing data | 34/52 (65.4) | 1.25 (0.84, 1.85) | |
| PTH [pg/mL] | 0.005 | ||
| < 600 | 303/476 (63.7) | References | |
| 600–< 1000 | 206/283 (72.8) | 1.32 (1.11, 1.58) | |
| ≥ 1000 | 101/146 (69.2) | 1.26 (0.99, 1.60) | |
Q quartile
aEastern Europe: Czech Republic, Hungary, Poland, Romania, Russia, Serbia, Slovak Republic, Slovenia and Turkey
bWestern Europe: France, Ireland, Italy, and the United Kingdom
cIberian Peninsula: Portugal and Spain